منابع مشابه
Molecular Genetics of Bipolar Disorder
................................................................................................................ 3 TABLE OF CONTENTS ................................................................................................ 5 ACKNOWLEDGEMENTS ............................................................................................ 11 LIST OF FIGURES .......................................
متن کاملGenetics of bipolar disorder.
Studies of families and twins show the importance of genetic factors affecting susceptibility to bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and replicable genome-wide significant associations have recently been reported in genome-wide association studies at several common polymorphisms, including variants within the genes CACNA1C, ODZ4, and NCAN. Strong e...
متن کاملGenetics of bipolar disorder.
In this chapter, we will attempt to outline the current state of genetic knowledge for bipolar disorder and briefly summarize the main findings from genetic epidemiology studies. We then review the most recent original literature, based largely on genome-wide association study methods. We conclude with some ideas about future directions.
متن کاملGenetics of bipolar disorder
Bipolar disorder especially the most severe type (type I), has a strong genetic component. Family studies suggest that a small number of genes of modest effect are involved in this disorder. Family-based studies have identified a number of chromosomal regions linked to bipolar disorder, and progress is currently being made in identifying positional candidate genes within those regions. A number...
متن کاملGenetics of bipolar disorder
Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs) and bipolar disorder. Currently, attempts are und...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2005
ISSN: 1601-1848,1601-183X
DOI: 10.1111/j.1601-183x.2005.00138.x